Early blood-spinal cord barrier stabilization preserves peri-lesional tissue and improves recovery after SCI
Chen Chen, Yan Sun, Xiaolong Du, Seung Young Lee, Xiaoting Wang, Qi Han, Wenhui Xiong, Xiangbing Wu, Yiping Zhang, Christopher B. Shields, Xiaoming Jin, Ji‐Xin Cheng, Wei Wu
This study identifies early vascular leakage beyond the injury epicenter as a driver of secondary pathology after SCI and shows that stabilizing the blood-spinal cord barrier improves recovery.
bioRxiv · Dec 7, 2025 · PreprintPathology