Ji‐Xin Cheng

Structural and compositional profiling of individual biomolecular assemblies by infrared absorbance-modulated evanescent scattering

This paper introduces IR-AMES, a technique for ultrasensitive structural and compositional analysis of individual biomolecular assemblies in aqueous environments, revealing insights into tau oligomers and their interactions with membranes.

Blood-Mediated Opto-Acoustic Stimulation of Brain Cortex at Sub-millimeter Precision

This paper introduces blood-mediated optoacoustic stimulation (BOAS) for precise brain cortex stimulation, showing it can trigger neuronal activity comparable to natural visual stimulation and is more efficient than photothermal methods.

Distinguishing Photoacoustic and Photothermal Neuron Stimulation Through Quantitative Mapping Spatiotemporal Field Evolution

This paper distinguishes photoacoustic and photothermal neuron stimulation by mapping their spatiotemporal field evolution, finding neurons are more responsive to photoacoustic stimulation.

SPEND-hSRS imaging of fumarate uncovers mitochondrial metabolic heterogeneity

The paper uses SPEND-hSRS imaging to visualize fumarate in bladder cancer cells, revealing mitochondrial metabolic heterogeneity and interactions with lipid droplets.

Mid-Infrared Photothermal Imaging Unveils Altered Stearoyl-CoA desaturase (SCD) Activity in Ovarian Cancer Cells

This study uses mid-infrared photothermal imaging to measure SCD activity in ovarian cancer cells and finds altered activity in treated cells and cancer stem cells.

Cholesterol metabolism modulation facilitates CAR-T induced killing of ovarian cancer

This study shows that modulating cholesterol metabolism in ovarian cancer cells enhances CAR-T cell cytotoxicity by disrupting lipid storage mechanisms.

A flexible high-precision photoacoustic retinal prosthesis

This paper presents a photoacoustic retinal prosthesis that stimulates retinal cells with high precision and safety, showing neural modulation in rat models.

Early blood-spinal cord barrier stabilization preserves peri-lesional tissue and improves recovery after SCI

This study identifies early vascular leakage beyond the injury epicenter as a driver of secondary pathology after SCI and shows that stabilizing the blood-spinal cord barrier improves recovery.

Mid-Infrared Photothermal Mesoscopy with Millimeter Field of View and Sub-micron Spatial Resolution

This paper introduces a mid-infrared photothermal mesoscope with millimeter-scale field of view and sub-micron resolution, enabling in vivo chemical imaging and Alzheimer's disease biomarker detection.

Genome-wide CRISPR screen reveals Wnt signaling defects regulate lipid accumulation in APOE4 oligodendrocytes

The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.

Ultrasensitive in vivo infrared spectroscopic imaging via oblique photothermal microscopy

This paper introduces an oblique photothermal microscope (OPTM) for ultrasensitive in vivo IR spectroscopic imaging with sub-micron resolution, enabling low-dose imaging of skin and tracking of topical drugs.

Highly reproduceable tapered fiber optoacoustic emitters by in-situ photothermal curing of PDMS for single neuron stimulation

The paper describes a method to create highly reproducible optoacoustic emitters for precise neural stimulation and demonstrates their effectiveness in vitro.

Bi-modal microwave neuromodulation via thermal and nonthermal mechanisms

This paper demonstrates bi-modal microwave neuromodulation through thermal and non-thermal mechanisms using a microwave rod antenna, enabling wireless treatment of seizures and chronic pain.

Click-free imaging of carbohydrate trafficking in live cells using an azido photothermal probe

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.

High-precision photoacoustic neural modulation uses a non-thermal mechanism

This study compares photoacoustic and photothermal neuromodulation, finding that photoacoustic stimulation requires significantly less energy and involves mechano-sensitive channels.

Longitudinal single-cell chemical imaging of engineered strains reveals heterogeneity in fatty acid production

This study uses longitudinal single-cell chemical imaging to reveal fatty acid production heterogeneity in engineered E. coli strains over time.

High-precision neural stimulation by a highly efficient candle soot fiber optoacoustic emitter

This paper develops a candle soot fiber optoacoustic emitter for high-precision neuromodulation, achieving tenfold higher efficiency than existing carbon-based emitters.

Neural Stimulation in vitro and in vivo by Photoacoustic Nanotransducers

This paper introduces photoacoustic nanotransducers for precise non-genetic neural stimulation in vitro and in vivo with high spatial and temporal resolution.

Optoacoustic brains stimulation at submillimeter spatial precision

This paper introduces a miniaturized Fiber-Optoacoustic Converter for high spatial precision neural stimulation in mice, achieving submillimeter resolution in vivo.