Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation
Garrett Klokman, YongYao Xu, Kyle Bond, Xiaoqiu Wu, Joshua Schustak, Jorgi Mandelbaum, Michael Twarog, Hongwei Han, Mary-Kate Paulina, Matthew Coble, Christopher Hayden, Jean-Rene Galarneau, John Demirs, Yubin Qiu, Robert Esterberg, , Yi Bao
This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.
bioRxiv · Mar 11, 2024 · PreprintCell Biology