Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System
Chia Ling Huang, Yubin Qiu, John T. Demirs, Xiaoqiu Wu, Michael Twarog, Omar Delgado, Maura A. Crowley, Natasha M. Buchanan, Nhi Vo, Lin Fan, Yanqun Wang, Junzheng Yang, Thomas R. Vollmer, Garrett Klokman, Sandra Jose, , Sha-Mei Liao
This study uses bulk RNA sequencing on postmortem human eye tissue to identify gene and pathway changes associated with progression from intermediate to late-stage AMD, highlighting potential therapeutic targets.
bioRxiv · Jul 10, 2025 · PreprintNeuroscience