Author

YongYao Xu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Magali Saint‐GenieziD· 3 shared Michael TwarogiD· 2 shared Robert Esterberg· 2 shared Chia Ling HuangiD· 1 shared Christopher W. WilsoniD· 1 shared Ganesh PrasannaiD· 1 shared Heather MacLeodiD· 1 shared John T. Demirs· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

Magali Saint‐GeniezORCID

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Author profile →

3 papers

Recent·Most cited

APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium Cells

Sarah E. V. Richards, John T. Demirs, Sandra Jose, Lin Fan, YongYao Xu, Robert Esterberg, Chia Ling Huang, Christopher W. Wilson, Magali Saint‐Geniez, Sha-Mei Liao

This study investigates how APOE variants affect lipid trafficking in RPE cells, finding that APOE knockout and APOE2-expressing cells show lipid transport deficits, while APOE4-expressing cells upregulate APOE in response to lipid challenges.

bioRxiv · May 30, 2024 · PreprintCell Biology

Protective effect of P2Y receptors antagonism on stress-induced retinal degeneration

Yi Bao, Kyle Bond, Pauline Sarraf, Robert Esterberg, Megan Serpa, Michael Twarog, YongYao Xu, Heather MacLeod, Qian Huang, Magali Saint‐Geniez

This study shows that blocking P2Y receptors with suramin prevents stress-induced RPE and photoreceptor degeneration in vitro and in a zebrafish model.

bioRxiv · May 28, 2024 · PreprintCell Biology

Use of machine learning for quantification of retinal pigment epithelium tight junctions improves assay sensitivity

Yan Gao, Mark‐Anthony Bray, Michael Twarog, YongYao Xu, Natasha M. Buchanan, Yiyun Zhang, Quintus G. Medley, Magali Saint‐Geniez, Ganesh Prasanna, Qin Zhang

This paper develops a machine learning method to quantify ZO-1 changes in RPE cells, improving assay sensitivity for detecting TJ aberrations in AMD-related treatments.

bioRxiv · May 24, 2024 · PreprintBioinformatics