Ganesh Prasanna

This study shows ANGPTL7 affects immune cells in the optic nerve head, contributing to neurodegeneration in glaucoma, despite no effect on intraocular pressure.

This study compares proteomic profiles of aqueous humor and plasma between glaucoma and non-glaucomatous patients, identifying differentially abundant proteins linked to vascular integrity, inflammation, and neurodegeneration.

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

This study uses bulk RNA sequencing on postmortem human eye tissue to identify gene and pathway changes associated with progression from intermediate to late-stage AMD, highlighting potential therapeutic targets.

This paper introduces a multiparametric grading system to stratify post-mortem glaucoma tissue by disease severity using structural and molecular markers.

This paper develops a machine learning method to quantify ZO-1 changes in RPE cells, improving assay sensitivity for detecting TJ aberrations in AMD-related treatments.

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.