Impaired oxidative phosphorylation drives primary tumor escape and metastasis
Emily Nicole Arner, Erin Q. Jennings, Daniel R. Crooks, Christopher J. Ricketts, Melissa M. Wolf, Matthew A. Cottam, Emilie L. Fisher, Martin Lang, Nunziata Maio, Yuki Shibata, Evan Krystofiak, Logan M. Vlach, Zaid Hatem, Alexander M. Blatt, Darren R. Heintzman, , Jeffrey C. Rathmell
This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.
bioRxiv · Jan 8, 2025 · PreprintCancer Biology