Darren R. Heintzman

This study shows that TOP3 resolves both inter- and intra-molecular DNA intertwines during replication, promoting fork progression and daughter strand unlinking, especially when TOP2 is compromised.

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.