Evan Krystofiak

This paper develops a 4D GelMA-Cad/gelatin hydrogel for vascularized soft tissue bioprinting, showing improved print fidelity and matrix mechanics for tissue modeling.

QuantEM provides a vision transformer-based platform for EM data segmentation and analysis, achieving accurate zero-shot segmentation with less data than existing models.

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

This study identifies exosomes carrying THSD7A as regulators of filopodia formation in both cancer cells and neurons, mediated through Cdc42 activation.

The paper shows that intermicrovillar adhesion complexes limit bacterial attachment to the small intestine brush border, with SFB remodeling actin to anchor to epithelial junctions.

The paper identifies a targeted cell lysis mechanism driven by TcdE that facilitates toxin release in Clostridioides difficile, revealing it as a bet-hedging strategy.

The paper shows that apical clathrin-coated pits regulate microvillar growth by controlling their location, timing, and size during epithelial differentiation.

This study shows that exosomes initiate fibronectin assembly in vitro and in vivo, reducing tumor growth and fibrosis.

This study identifies FapR as a regulator of HssRS-mediated heme homeostasis in B. anthracis, showing its role in maintaining membrane integrity and HssS localization.

This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.

This study uses advanced microscopy to reveal the ultrastructural organization of tuft cell cytoskeleton, showing co-aligned actin bundles and microtubules.

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.