A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I
Ahmed Seddek, Christian Madeira, Thirunavukkarasu Annamalai, Christopher Mederos, Purushottam Babu Tiwari, Aaron Z. Welch, Yuk‐Ching Tse‐Dinh
This paper develops a yeast-based screening system to identify human TOP1 poison inhibitors and catalytic inhibitors, distinguishing their mechanisms and assessing cytotoxicity.
bioRxiv · Nov 16, 2021 · PreprintMolecular Biology