Author

Thirunavukkarasu Annamalai

Florida International University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Organism:yeast· 1

Frequent Co-Authors

Yuk‐Ching Tse‐DinhiD· 2 shared Aaron Z. WelchiD· 1 shared Ahmed SeddekiD· 1 shared Christian Madeira· 1 shared Christopher Mederos· 1 shared Fenfei LengiD· 1 shared Prem P. ChapagainiD· 1 shared Purushottam Babu TiwariiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Yuk‐Ching Tse‐DinhORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 5, 2026

Investigation of potential hinge region for Mycobacterium tuberculosis topoisomerase I conformational change during catalysis

Shomita Ferdous, Yasir Mamun, Thirunavukkarasu Annamalai…·Yuk‐Ching Tse‐Dinh

The paper identifies a potential hinge region in MtbTOP1 critical for conformational changes during DNA relaxation, showing that mutations disrupt enzyme activity.

DOI 10.64898/2026.02.04.703551

protein structureexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintNov 16, 2021

A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I

Ahmed Seddek, Christian Madeira, Thirunavukkarasu Annamalai…·Yuk‐Ching Tse‐Dinh

This paper develops a yeast-based screening system to identify human TOP1 poison inhibitors and catalytic inhibitors, distinguishing their mechanisms and assessing cytotoxicity.

DOI 10.1101/2021.11.16.468530

yeastexperimental assay

𝕏 PostBluesky