Yuk‐Ching Tse‐Dinh

This study shows that fluoroquinolone susceptibility in Chlamydia trachomatis depends on stage-specific DNA supercoiling levels, with treatment affecting growth and persistence through inhibition of DNA replication and gyrase activity.

The paper studies how C-terminal deletions in Mycobacterium topoisomerase IA affect supercoil relaxation using single-molecule magnetic tweezers.

The paper identifies a potential hinge region in MtbTOP1 critical for conformational changes during DNA relaxation, showing that mutations disrupt enzyme activity.

This study shows that Chlamydia trachomatis TopA, containing a SWIB domain, mediates DNA relaxation and is essential for bacterial growth and host interaction.

The paper identifies potential inhibitors of TOP3B using molecular dynamics and docking, showing that bemcentinib and its analogs inhibit TOP3B relaxation activity.

This paper develops a yeast-based screening system to identify human TOP1 poison inhibitors and catalytic inhibitors, distinguishing their mechanisms and assessing cytotoxicity.