The mouse Cdh23ahl allele drives early cochlear dysfunction and phenotypic heterogeneity before progressive hearing loss
Sherylanne Newton, Marisa Flook, Christopher Shults, Pavandeep Gill, Carlos Aguilar, Wei Song, Michelle E Stewart, Sara Wells, Ronna Hertzano, Jing-Yi Jeng, Michael R Bowl
This study shows the Cdh23ahl allele causes early cochlear dysfunction and phenotypic variability in mice before progressive hearing loss, with altered mechanoelectrical transduction and transcriptional changes.
bioRxiv · Nov 3, 2026 · PreprintGenetics