Albert S.B. Edge

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

A gamma-secretase inhibitor regenerates hair cells and afferent neurons in a mouse model, restoring balance function.

This study shows that regenerated IHC synapses in vitro are functional and exhibit glutamatergic currents, with older cultures showing more mature release properties.

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

The paper identifies transcriptional and epigenetic programs driving hair cell differentiation from supporting cells in cochlear organoids and predicts novel regulatory factors.

This study compares human iPSC-derived inner ear organoids with early embryonic inner ear tissue, showing they recapitulate key developmental stages and marker expression.

This study shows that an anti-RGMa antibody promotes regeneration of cochlear synapses after noise exposure, leading to recovery of auditory brainstem response amplitude.

Trk agonist drugs, including amitriptyline and 7,8-dihydroxyflavone, rescue noise-induced cochlear synaptopathy through synaptic regeneration, with long-lasting effects observed after systemic delivery.