Mahashweta Basu

A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

Nucleus accumbens neuron subtype translatome signatures in socially stress females

The paper identifies female-specific transcriptional changes in nucleus accumbens neuron subtypes under chronic social stress and highlights PI3K-Akt-mTOR signaling as a conserved pathway.

The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons

The paper identifies sex-biased gene expression in the juvenile rat medial amygdala associated with playfulness, showing inhibitory neurons drive this difference.

Transcriptional signatures of fentanyl use in the mouse ventral tegmental area

This study identifies transcriptional changes in mouse VTA cell types after fentanyl self-administration using single nuclei RNA sequencing.

Cochlear organoids reveal epigenetic and transcriptional programs of postnatal hair cell differentiation from supporting cells

The paper identifies transcriptional and epigenetic programs driving hair cell differentiation from supporting cells in cochlear organoids and predicts novel regulatory factors.

Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice

This study examines transcriptomic changes in reward and sensory brain regions of juvenile mice exposed to perinatal fentanyl, revealing sex-specific gene expression patterns and enriched biological processes.

Molecular, circuit, and stress response characterization of Ventral Pallidum Npas1-neurons

The paper characterizes VP Npas1+ neurons' projections, molecular identity, and role in stress response through RNA-seq and chemogenetic manipulation.

Multimodal interrogation of ventral pallidum projections reveals projection-specific signatures and opposite roles in cocaine withdrawal

This study identifies distinct transcriptomic, physiological, and functional properties of four VP projections and shows their opposing roles in cocaine withdrawal.

Predicting tissue-specific gene expression from whole blood transcriptome

This study predicts tissue-specific gene expression from whole blood transcriptome using GTEx data, finding that blood expression can predict expression in many tissues and improve disease prediction.

A transcription-centric model of SNP-Age interaction

The paper introduces SNiPage, a framework to identify SNP-age interactions in transcriptional control, finding 637 TF-SNP-Gene triplets across 25 tissues linked to aging and age-related diseases.