Cytokinesis Arrest-induced Binucleation of Macrophages ProducesHighly Efficient Efferocytes
Xun Wu, Ziyi Wang, Chenyi Xue, Fang Li, Jinnan Yue, Tyler Shern, Wenli Liu, Jian Cui, Christopher W. Wu, Michael Kissner, Lars Mäegdefessel, Ira A. Tabas, Alan R. Tall, Hanrui Zhang
The paper shows that cytokinesis arrest in macrophages leads to binucleation, which enhances efferocytic function and reduces autoimmune responses.
bioRxiv · Aug 11, 2026 · PreprintCell Biology