Hanrui Zhang

The paper shows that cytokinesis arrest in macrophages leads to binucleation, which enhances efferocytic function and reduces autoimmune responses.

This study examines how plasma Lp(a) levels and monocyte subsets differ between Black and White individuals using scRNA-seq, finding race modifies associations between Lp(a) and monocyte proportions.

This study integrates single-cell spatial transcriptomics with bulk and single-cell RNA sequencing to reveal the molecular heterogeneity and mechanisms of atherosclerotic carotid artery plaques.

This study shows WDFY3 protects against autoimmunity by enhancing macrophage efferocytosis, reducing autoantigen release, and suppressing T cell and inflammasome activation.

This study shows G1 and G2 APOL1 variants increase macrophage inflammation and lipid accumulation via the polyamine pathway, which can be inhibited by DFMO.

This study shows that ASO treatment rescues oligodendrocyte dysfunction in SCA3 mice by targeting mutant ATXN3, suggesting potential for glial-targeted therapies in neurodegenerative diseases.

The paper uses multimodal single-cell profiling to identify diverse monocyte subtypes and links them to cardiovascular disease risk factors.

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

ASEP detects gene-level allele-specific expression in populations using RNA-seq, identifying differential ASE between conditions and extending findings to cardiometabolic traits.