Ira A. Tabas

This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.

This study identifies YY1 phosphorylation as a key mechanism linking non-apoptotic caspase-8 signaling to METRN induction and MASH fibrosis.

The paper shows that cytokinesis arrest in macrophages leads to binucleation, which enhances efferocytic function and reduces autoimmune responses.

This study integrates single-cell spatial transcriptomics with bulk and single-cell RNA sequencing to reveal the molecular heterogeneity and mechanisms of atherosclerotic carotid artery plaques.

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

This study shows that MK2 inhibitors TBX-1 and TBX-2 improve glucose metabolism and reduce atherosclerotic plaque instability in mice with established atherosclerosis.