Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression
Shuangzhou Peng, Bin Zhang, Le Jin, Huixin Xu, Bastian Stielow, Merle Geller, Chuanying Wang, Mengyu Zhang, Xianglong Luo, Xijiao Wang, Meizhi Jiang, Xiang Gao, Xiaokun Zhang, Qixu Cai, Fei Sun, , Siming Chen
This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.
bioRxiv · Mar 26, 2025 · PreprintBiochemistry