Qixu Cai

PXDesign: Fast, Modular, and Accurate De Novo Design of Protein Binders

PXDesign achieves high hit rates for protein binder design by combining generative models and filtering strategies, validated experimentally and made publicly available.

Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression

This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.

CaMKII autophosphorylation but not downstream kinase activity is required for synaptic memory

This study identifies that CaMKII autophosphorylation and binding to GluN2B are necessary for synaptic memory, while kinase activity is not required.

CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.