Author

Le Jin

Xiamen UniversityORCID 0000-0002-7203-3632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Meizhi Jiang· 2 shared Rui Gao· 2 shared Siming CheniD· 2 shared Bastian StielowiD· 1 shared Bin ZhangiD· 1 shared Bin ZhangiD· 1 shared Chen XieiD· 1 shared Chenyu Xu· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Meizhi Jiang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression

Shuangzhou Peng, Bin Zhang, Le Jin, Huixin Xu, Bastian Stielow, Merle Geller, Chuanying Wang, Mengyu Zhang, Xianglong Luo, Xijiao Wang, Meizhi Jiang, Xiang Gao, Xiaokun Zhang, Qixu Cai, Fei Sun, , Siming Chen

This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.

bioRxiv · Mar 26, 2025 · PreprintBiochemistry

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4-Mediated Immune Evasion in Acute Monocytic Leukemia

Fangfang Huang, Xiang Luo, Mengyu Zhang, Le Jin, Wenxin Sun, Peihan Chen, Xiuli Hong, Chenyu Xu, Meizhi Jiang, Die Hu, Bin Zhang, Shengwei Hu, Chuanjiang Yang, Rui Gao, Jin-Zhang Zeng, , Siming Chen

This study shows that homoharringtonine promotes FTO degradation, reducing LILRB4 expression and enhancing immune recognition in acute monocytic leukemia.

bioRxiv · Mar 15, 2025 · PreprintCancer Biology

Retinal glial cells under hypoxia possibly function in mammalian myopia by responding to mechanical stimuli, affecting hormone metabolism and peptide secretion

Xuhong Zhang, Yingying Wen, Le Jin, Dongyan Zhang, Liyue Zhang, Chen Xie, Dongyu Guo, Jianping Tong, Ye Shen

The paper investigates the role of retinal glial cells under hypoxia in mammalian myopia by analyzing gene expression and pathways related to mechanical stimuli and hormone metabolism.

bioRxiv · Nov 26, 2020 · PreprintBioinformatics