Author

Bastian Stielow

Philipps University of MarburgORCID 0000-0002-3284-0712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Merle Geller· 3 shared Robert LiefkeiD· 3 shared Andrea NistiD· 2 shared Clara SimoniD· 2 shared Ignasi FornéiD· 2 shared Lisa Marie WeberiD· 2 shared Sabrina Fischer· 2 shared Thorsten StieweiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersMolecular Biology

Merle Geller

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3 papers

Recent·Most cited

Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression

Shuangzhou Peng, Bin Zhang, Le Jin, Huixin Xu, Bastian Stielow, Merle Geller, Chuanying Wang, Mengyu Zhang, Xianglong Luo, Xijiao Wang, Meizhi Jiang, Xiang Gao, Xiaokun Zhang, Qixu Cai, Fei Sun, , Siming Chen

This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.

bioRxiv · Mar 26, 2025 · PreprintBiochemistry

SAMD1 suppresses epithelial-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma

Clara Simon, Inka D. Brunke, Bastian Stielow, Ignasi Forné, Anna Mary Steitz, Merle Geller, Iris Rohner, Lisa Marie Weber, Sabrina Fischer, Lea Marie Jeude, Theresa Huber, Andrea Nist, Thorsten Stiewe, Magdalena Huber, Malte Buchholz, Robert Liefke

This study identifies SAMD1 as a repressor of EMT-related genes in PDAC, showing that its loss increases migration and that FBXO11 ubiquitinates SAMD1 to inhibit its function.

PLoS Biology · Aug 13, 2024Peer-reviewedMolecular Biology

IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells

Sabrina Fischer, Lisa Marie Weber, Bastian Stielow, Miriam Frech, Clara Simon, Merle Geller, Julie Könnecke, Florian Finkernagel, Ignasi Forné, Andrea Nist, Uta‐Maria Bauer, Thorsten Stiewe, Andreas Neubauer, Robert Liefke

This study shows IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent excessive inflammation in AML cells, revealing a potential therapeutic target.

Nucleic Acids Research · May 14, 2024Peer-reviewedMolecular Biology