DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity
J. Richard Brewer, Ailin Han, Amin H. Nassar, Elias Bou Farhat, Holly N. Blackburn, Tianli Xiao, Haris Mirza, Walter K. Mowel, Esen Sefik, Saskia Hartner, Michael Chiorazzi, Takeshi Ito, Min Hee Oh, Matthew Z. Madden, Athreya S Rangavajhula, , Richard Anthony Flavell
The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.
bioRxiv · Jul 3, 2026 · PreprintImmunology