Tianli Xiao

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.