Author

Holly N. Blackburn

Yale UniversityORCID 0000-0003-2759-3216Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Richard Anthony FlavelliD· 3 shared Ailin Han· 2 shared Amin H. NassariD· 2 shared Esen SefikiD· 2 shared Fengrui ZhangiD· 2 shared Haris MirzaiD· 2 shared J. Richard Brewer· 2 shared Matthew Z. MaddeniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Richard Anthony FlavellORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologyJournal of Clinical InvestigationPeer-reviewedSep 14, 2026

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

Tianli Xiao, J. Richard Brewer, Maximillian J. Carlino…·Richard Anthony Flavell

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

DOI 10.1172/jci207530

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 3, 2026

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity

J. Richard Brewer, Ailin Han, Amin H. Nassar…·Richard Anthony Flavell

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

DOI 10.64898/2026.06.30.735609

humanmouse

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 24, 2025

FABP5 regulates ether lipid metabolism to ameliorate atopic dermatitis

Mathias H. Skadow, Walter K. Mowel, Holly N. Blackburn…·Richard Anthony Flavell

This study shows FABP5 regulates ether lipid metabolism, reducing inflammation in atopic dermatitis by modulating platelet activating factor levels.

DOI 10.1101/2025.10.24.684205

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 19, 2025

CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon

Jessica N. Buck, Nivedita R. Iyer, Eric Fagerberg…·Nikhil S. Joshi

This study shows CD8 T cells eliminate neoantigen+ epithelial stem cells in the colon, preventing cancer, without causing immunopathology.

1 citation

mousespatial transcriptomics

𝕏 PostBluesky