Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.
Anthony W. Martinelli, Chun-Pei Wu, Tristan Vornbäumen, Hudson W. Coates, Louise Jordon, Niek Wit, Jia Jhing Sia, Anneliese O. Speak, James A. Nathan
The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.
Science Advances · Sep 17, 2025Peer-reviewedCell Biology