James A. Nathan

Regulation of proteasome activation by a ubiquitin-independent feedback mechanism

This study identifies ZFAND5/6 as ubiquitin-independent proteasome activators that regulate NF-κB signaling by degrading UBCH5c.

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.

This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.

VHL synthetic lethality screens uncover CBF-beta as a negative regulator of STING

The paper identifies CBF-beta as a negative regulator of STING through synthetic lethality screens in VHL-null ccRCC cells, showing its role in type I interferon signaling and tumor growth.

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

Hypoxia promotes airway differentiation in the human lung epithelium

This study shows hypoxia promotes airway differentiation in human lung epithelial progenitors through HIF pathways, with implications for lung disease.

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.

The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.

Developmental changes in the carotid body transcriptome accompanying the maturation of chemosensitivity

This study identifies gene expression changes in the carotid body transcriptome across developmental stages in sheep, correlating with the maturation of oxygen chemosensitivity.

ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism

This study identifies ABHD11 as a deglutarylating enzyme that regulates T cell metabolism by maintaining TCA cycle integrity through removal of glutaryl-lipoyl adducts.

ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.