Anneliese O. Speak

This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.

The paper identifies novel regulators of NK cell development and antiviral function through in vivo screening in mice, with relevance to human health.

The paper identifies CBF-beta as a negative regulator of STING through synthetic lethality screens in VHL-null ccRCC cells, showing its role in type I interferon signaling and tumor growth.

The paper introduces TGlow, a high-content imaging platform for single-cell phenotyping of human lymphocytes, revealing distinct morphological states and drug responses.

The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.

The paper develops an in vitro model of CD8 T cell exhaustion and identifies a gene signature that defines the exhausted state in both in vitro and in vivo settings, with validation in human tumor samples.

This paper introduces TraCeR, a method to infer full-length TCR sequences from single-cell RNA-seq, revealing clonal relationships and linking them to T cell functional states in Salmonella infection.