Qing Richard Lu

Single-cell and Spatial Omics Reveals Region-Specific Plasticity and Therapeutic Vulnerabilities in Metastatic High-Risk Neuroblastoma

This study uses single-cell and spatial omics to identify plasticity and therapeutic targets in metastatic high-risk neuroblastoma.

Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum

The paper validates the existence of transitional cerebellar progenitors using multimodal approaches across multiple datasets and stages.

SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma

This paper shows SUV39H1 is critical for maintaining glioblastoma stem cell properties and progression, and targeting it enhances chemotherapy effectiveness.

Spatial pattern and differential expression analysis with spatial transcriptomic data

This paper introduces SPADE, a method for identifying spatially variable genes in spatial transcriptomic data, showing improved performance over existing methods in both within and between-group analyses.

An Efficient and Principled Model to Jointly Learn the Agnostic and Multifactorial Effect in Large-Scale Biological Data

The paper introduces CMC, a model that efficiently learns multifactorial effects in biological data and outperforms existing methods in several applications.

Inhibition of adrenergic b1-AR/Gas signaling promotes cardiomyocyte proliferation through activation of RhoA-YAP axis

This study shows that inhibiting β1-AR/Gs signaling promotes cardiomyocyte proliferation and cardiac regeneration in mice by activating the RhoA-YAP axis.

Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse Brain

This study shows that Tet1-mediated DNA hydroxymethylation is essential for myelination and remyelination in mice by regulating oligodendrocyte differentiation and calcium signaling.