Ribosome biogenesis bottlenecks reveal vulnerabilities in cancer
Lifei Jiang, Qiwei Yu, Sofia A. Quinodoz, Jordy F. Botello, Sabreen Alam, Jing Xia, Jonida Trako, Troy J. Comi, Aya A. Abu-Alfa, Yong Wei, Andrej Košmrlj, Yibin Kang, Clifford P. Brangwynne
This study identifies late-stage processing bottlenecks in ribosome biogenesis caused by oncogene activation, which impair ribosome production and limit tumor growth.
bioRxiv · Apr 21, 2026 · PreprintCell Biology