Transient signaling of free ADP-ribose monitored with an intracellular biosensor
Shivansh Goyal, Vanna Nguyen, Scott N. Lyons, Tyler L. Dangerfield, Wanjie Yang, Ciara Fields, Hsin‐Ru Chan, Yazhini Mahendravarman, Lorren Cantú, Nesha Rubin, Kelton Deloney, Kenneth Allen Johnson, Xiaolu A. Cambronne
The paper develops a biosensor to measure intracellular ADP-ribose dynamics and finds that ADPR levels are transient, tunable, and critical for TRPM2 activation.
bioRxiv · Feb 9, 2026 · PreprintBiochemistry