Author

Scott N. Lyons

The University of Texas at Austin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Hsin‐Ru Chan· 2 shared Xiaolu A. CambronneiD· 2 shared 5· 1 shared Bradley A. WebbiD· 1 shared Ciara Fields· 1 shared Congcong Lyu· 1 shared Crystal N. WilsoniD· 1 shared Eric M. LynchiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

Hsin‐Ru Chan

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A Covalent PFKL Activator Suppresses Tumor Growth

Xiaoding Jiang, Eric M. Lynch, Congcong Lyu, Crystal N. Wilson, Lauren E. Salay, Hayden T. Hess, Scott N. Lyons, Shuangyu Luo, Gibae Kim, Hsin‐Ru Chan, 5, Lauren G. Zacharias, Thomas P. Mathews, Yi‐Chih Lin, Bradley A. Webb, , Ku‐Lung Hsu

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

Nature Chemical Biology · Aug 5, 2026Peer-reviewedBiochemistry

Transient signaling of free ADP-ribose monitored with an intracellular biosensor

Shivansh Goyal, Vanna Nguyen, Scott N. Lyons, Tyler L. Dangerfield, Wanjie Yang, Ciara Fields, Hsin‐Ru Chan, Yazhini Mahendravarman, Lorren Cantú, Nesha Rubin, Kelton Deloney, Kenneth Allen Johnson, Xiaolu A. Cambronne

The paper develops a biosensor to measure intracellular ADP-ribose dynamics and finds that ADPR levels are transient, tunable, and critical for TRPM2 activation.

bioRxiv · Feb 9, 2026 · PreprintBiochemistry