Xiaolu A. Cambronne

A Covalent PFKL Activator Suppresses Tumor Growth

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

Domain-Specific Agonist Binding Affinities Explain Structural and Functional Regulation of TRPM2

This study quantifies the binding affinities of TRPM2 domains for ADPR analogs and shows that MHR1/2 drives activation while NUDT9H maintains structural integrity.

Transient signaling of free ADP-ribose monitored with an intracellular biosensor

The paper develops a biosensor to measure intracellular ADP-ribose dynamics and finds that ADPR levels are transient, tunable, and critical for TRPM2 activation.