Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids
Bárbara F. Fonseca, Cindy Barbée, Mírian Romitti, Sema Elif Eski, Pierre Gillotay, Daniel Monteyne, David L. Pérez-Morga, Samuel Refetoff, Sumeet Pal Singh, Sabine Costagliola
This study shows that Foxe1 knockout in mouse stem cells leads to lung lineage derivation over thyroid lineage, using single-cell RNA sequencing and chromatin profiling.
bioRxiv · May 16, 2022 · PreprintDevelopmental Biology