Sabine Costagliola

Microphysiological Flow Batteries For Dynamic EDC Screening Of mESC-derived Thyroid Organoids

The paper introduces a thyroid-on-chip platform using mouse embryonic stem cell-derived thyroid organoids to dynamically screen endocrine disrupting chemicals (EDCs) and identify molecular signatures of thyroid disruption.

Microfluidic bioprinting of a physiologically relevant thyroid three-dimensional in vitro model

This study develops a 3D thyroid in vitro model using microfluidic bioprinting to test endocrine disruptors and assess their effects.

Long-term prevention of aneuploidy in human pluripotent stem cells by fine-tuning GSK3 activity

This study shows that low-dose GSK3 inhibitors prevent aneuploidy in hPSCs by reducing mitotic DNA synthesis and ultra-fine chromosome bridges during long-term culture.

Mesodermal FGF and BMP govern the multi-step thyroid specification

This study identifies the role of FGF and BMP signaling in thyroid progenitor specification in zebrafish embryos, showing FGF regulates Pax2a and BMP regulates both Pax2a and Nkx2.4b.

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

This study generates transplantable human thyroid organoids from embryonic stem cells that restore thyroid hormone levels in athyreotic mice.

Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids

This study shows that Foxe1 knockout in mouse stem cells leads to lung lineage derivation over thyroid lineage, using single-cell RNA sequencing and chromatin profiling.

Nrf2 promotes thyroid development and hormone synthesis.

This study shows that NRF2 regulates thyroglobulin expression in zebrafish and mouse thyroid organoids to manage oxidative stress during thyroid hormone synthesis.

Single-cell trajectory inference guided enhancement of thyroidmaturation in vitro using TGF-beta inhibition

The paper improves thyroid organoid maturation in vitro by identifying TGF-beta and PCP pathways using single-cell RNA-Seq and pharmacological manipulation.

Single-cell transcriptome analysis reveals cell-cell communication and thyrocyte diversity in the zebrafish thyroid gland

The paper uses single-cell transcriptomics to reveal heterogeneity in zebrafish thyroid thyrocytes and characterizes surrounding cell types.

Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects

This study shows that enhanced Wnt signaling during zebrafish development disrupts cardiac mesoderm-endoderm interactions, leading to thyroid specification defects and cardiovascular abnormalities.

Small Molecule Screening in Zebrafish Embryos Identifies Signaling Pathways Regulating Early Thyroid Development

The paper identifies BMP and FGF signaling as key regulators of thyroid development in zebrafish embryos through small molecule screening and links these findings to conserved vertebrate mechanisms.