Pierre Gillotay

The paper identifies hoxb5a as a critical regulator of spinal cord regeneration in zebrafish by analyzing transcriptional and microenvironmental differences between successful and failed regeneration cases.

This study identifies the role of FGF and BMP signaling in thyroid progenitor specification in zebrafish embryos, showing FGF regulates Pax2a and BMP regulates both Pax2a and Nkx2.4b.

This study generates transplantable human thyroid organoids from embryonic stem cells that restore thyroid hormone levels in athyreotic mice.

This study shows that Foxe1 knockout in mouse stem cells leads to lung lineage derivation over thyroid lineage, using single-cell RNA sequencing and chromatin profiling.

This study shows that NRF2 regulates thyroglobulin expression in zebrafish and mouse thyroid organoids to manage oxidative stress during thyroid hormone synthesis.

The paper improves thyroid organoid maturation in vitro by identifying TGF-beta and PCP pathways using single-cell RNA-Seq and pharmacological manipulation.

The paper uses single-cell transcriptomics to reveal heterogeneity in zebrafish thyroid thyrocytes and characterizes surrounding cell types.

This study shows that enhanced Wnt signaling during zebrafish development disrupts cardiac mesoderm-endoderm interactions, leading to thyroid specification defects and cardiovascular abnormalities.

The paper identifies BMP and FGF signaling as key regulators of thyroid development in zebrafish embryos through small molecule screening and links these findings to conserved vertebrate mechanisms.