Sumeet Pal Singh

PTPRF is a stress responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

Alcohol-Evoked Calcium Signaling Drives Distinct Responses in Zebrafish Hepatocytes and Pancreatic Acinar Cells

This study shows alcohol exposure causes shared calcium signaling changes in zebrafish hepatocytes and pancreatic acinar cells, with tissue-specific molecular mechanisms involved.

Rhpn2 promotes zebrafish melanoma development and aggressiveness in vivo

This study shows Rhpn2 promotes zebrafish melanoma development and aggressiveness by enhancing tumor growth and invasion.

CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages

CellCousin2 improves lineage tracing in zebrafish by reducing background recombination and enhancing ablation efficiency with a new system.

Loss of PTPRK in hepatocytes reduces steatosis and carcinogen-induced tumour development in obesity

This study shows that loss of PTPRK in hepatocytes reduces steatosis and tumour development in obesity-induced hepatocellular carcinoma.

Wnt7a is a Novel Lymphangiocrine Factor Driving Cholangiocyte Proliferation during Liver Regeneration

This study identifies Wnt7a as a lymphangiocrine factor that promotes cholangiocyte proliferation during liver regeneration in both rodent and human models.

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

This study shows that cholangiocytes generate new hepatocytes during zebrafish liver regeneration after partial injury during growth.

Feeding induces c-Fos in hepatocytes contributing to hepatocellular carcinoma in obesity

This study shows that c-Fos in hepatocytes promotes MASLD and HCC by altering metabolic pathways and signaling networks in obesity.

Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression

The paper uses volumetric imaging and single-cell RNAseq to study human dental pulp responses during tooth decay, identifying cellular mechanisms and progression stages.

Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish

Dedifferentiated fibroblasts sequentially induce and resolve neutrophil-driven inflammation through cytokine release to facilitate axon regeneration after spinal cord injury in zebrafish.

Epigenetic Disordering Drives Stemness, Senescence Escape and Tumor Heterogeneity

The paper shows that high UHRF1 levels in zebrafish hepatocytes cause epigenetic disordering, leading to stemness, senescence escape, and tumor heterogeneity in hepatocellular carcinomas.

A vasopressin circuit that modulates sex-specific social interest and anxiety-like behavior in mice

The paper identifies a vasopressin circuit in mice that modulates sex-specific social interest and anxiety-like behavior through projections from the BNST to the lateral septum.

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

This study shows that cellular senescence promotes progenitor cell expansion during axolotl limb regeneration by creating a pro-proliferative niche and modulating Wnt signaling.

A zebrafish knock-in reporter line for the Foxo1a transcription factor.

This paper develops a zebrafish knock-in reporter line for the Foxo1a transcription factor to enable in vivo imaging of its expression and localization.

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

This study generates transplantable human thyroid organoids from embryonic stem cells that restore thyroid hormone levels in athyreotic mice.

In vivo imaging of calcium dynamics in zebrafish hepatocytes

This study uses in vivo imaging in zebrafish to observe calcium dynamics in hepatocytes under various conditions, revealing oscillations, waves, and spikes.

Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids

This study shows that Foxe1 knockout in mouse stem cells leads to lung lineage derivation over thyroid lineage, using single-cell RNA sequencing and chromatin profiling.

Nrf2 promotes thyroid development and hormone synthesis.

This study shows that NRF2 regulates thyroglobulin expression in zebrafish and mouse thyroid organoids to manage oxidative stress during thyroid hormone synthesis.

A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.

Single-cell trajectory inference guided enhancement of thyroidmaturation in vitro using TGF-beta inhibition

The paper improves thyroid organoid maturation in vitro by identifying TGF-beta and PCP pathways using single-cell RNA-Seq and pharmacological manipulation.

Keratin dynamics govern the establishment of the maternal-fetal interface.

The paper investigates the role of keratin dynamics in post-implantation extra-embryonic membrane morphogenesis using live imaging and single-cell RNA sequencing in mouse embryos.

In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

The paper uses BioID2 proximity labeling to identify cardiomyocyte protein networks during zebrafish heart regeneration and finds Rho A is a target of ErbB2 signaling involved in muscle creation.

Single-cell transcriptome analysis reveals cell-cell communication and thyrocyte diversity in the zebrafish thyroid gland

The paper uses single-cell transcriptomics to reveal heterogeneity in zebrafish thyroid thyrocytes and characterizes surrounding cell types.

An asymmetry in the frequency and position of mitosis in the epiblast precedes gastrulation and suggests a role for mitotic rounding in cell delamination during primitive streak epithelial-mesenchymal transition.

The paper observes that non-apical mitosis in the posterior epiblast precedes gastrulation and is associated with cell delamination during epithelial-mesenchymal transition.

Machine learning based classification of cells into chronological stages using single-cell transcriptomics.

This paper introduces GERAS, a machine learning framework that classifies single-cell transcriptomes into chronological stages with high accuracy and identifies aging-related factors in zebrafish and human pancreatic cells.