Mírian Romitti

This study uses single nuclei RNA-seq and spatial transcriptomics to analyze transcriptional patterns in papillary and anaplastic thyroid cancers, revealing idiosyncratic and generic transcriptional variations and EMT-related features.

The paper introduces a thyroid-on-chip platform using mouse embryonic stem cell-derived thyroid organoids to dynamically screen endocrine disrupting chemicals (EDCs) and identify molecular signatures of thyroid disruption.

This study develops a 3D thyroid in vitro model using microfluidic bioprinting to test endocrine disruptors and assess their effects.

This study shows that low-dose GSK3 inhibitors prevent aneuploidy in hPSCs by reducing mitotic DNA synthesis and ultra-fine chromosome bridges during long-term culture.

This study generates transplantable human thyroid organoids from embryonic stem cells that restore thyroid hormone levels in athyreotic mice.

This study shows that Foxe1 knockout in mouse stem cells leads to lung lineage derivation over thyroid lineage, using single-cell RNA sequencing and chromatin profiling.

This study shows that NRF2 regulates thyroglobulin expression in zebrafish and mouse thyroid organoids to manage oxidative stress during thyroid hormone synthesis.

The paper improves thyroid organoid maturation in vitro by identifying TGF-beta and PCP pathways using single-cell RNA-Seq and pharmacological manipulation.