Sema Elif Eski

Alcohol-Evoked Calcium Signaling Drives Distinct Responses in Zebrafish Hepatocytes and Pancreatic Acinar Cells

This study shows alcohol exposure causes shared calcium signaling changes in zebrafish hepatocytes and pancreatic acinar cells, with tissue-specific molecular mechanisms involved.

CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages

CellCousin2 improves lineage tracing in zebrafish by reducing background recombination and enhancing ablation efficiency with a new system.

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

This study shows that cholangiocytes generate new hepatocytes during zebrafish liver regeneration after partial injury during growth.

Epigenetic Disordering Drives Stemness, Senescence Escape and Tumor Heterogeneity

The paper shows that high UHRF1 levels in zebrafish hepatocytes cause epigenetic disordering, leading to stemness, senescence escape, and tumor heterogeneity in hepatocellular carcinomas.

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

This study generates transplantable human thyroid organoids from embryonic stem cells that restore thyroid hormone levels in athyreotic mice.

Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids

This study shows that Foxe1 knockout in mouse stem cells leads to lung lineage derivation over thyroid lineage, using single-cell RNA sequencing and chromatin profiling.

A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.

Single-cell trajectory inference guided enhancement of thyroidmaturation in vitro using TGF-beta inhibition

The paper improves thyroid organoid maturation in vitro by identifying TGF-beta and PCP pathways using single-cell RNA-Seq and pharmacological manipulation.

Keratin dynamics govern the establishment of the maternal-fetal interface.

The paper investigates the role of keratin dynamics in post-implantation extra-embryonic membrane morphogenesis using live imaging and single-cell RNA sequencing in mouse embryos.

Single-cell transcriptome analysis reveals cell-cell communication and thyrocyte diversity in the zebrafish thyroid gland

The paper uses single-cell transcriptomics to reveal heterogeneity in zebrafish thyroid thyrocytes and characterizes surrounding cell types.

An asymmetry in the frequency and position of mitosis in the epiblast precedes gastrulation and suggests a role for mitotic rounding in cell delamination during primitive streak epithelial-mesenchymal transition.

The paper observes that non-apical mitosis in the posterior epiblast precedes gastrulation and is associated with cell delamination during epithelial-mesenchymal transition.