The integration of network biology and pharmacophore modeling suggests repurposing Clindamycin as an inhibitor of pyroptosis via Caspase-1 blockage in tumor-associated macrophages
Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer A, Carola Berking, Gerhard Krönke, Shailendra K. Gupta, Heiko Bruns, Julio Vera
The paper identifies Clindamycin as a potential inhibitor of pyroptosis in tumor-associated macrophages by integrating network biology and pharmacophore modeling.
Journal of Experimental & Clinical Cancer Research · Aug 4, 2025Peer-reviewedSystems Biology