Heiko Bruns

USP8 Controls Proteostasis Pathways in B Cells and Multiple Myeloma

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation

This study shows glycolytic flux supports human Th1 cell identity and effector function through STAT1 O-glycosylation, with inhibition of glycolysis or O-glycosylation reducing IFN-gamma production.

Antigen receptor competition in CAR-TCR cells changes cytotoxicity outcomes upon spatial antigen separation

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

The integration of network biology and pharmacophore modeling suggests repurposing Clindamycin as an inhibitor of pyroptosis via Caspase-1 blockage in tumor-associated macrophages

The paper identifies Clindamycin as a potential inhibitor of pyroptosis in tumor-associated macrophages by integrating network biology and pharmacophore modeling.