Gerhard Krönke

This study shows that unmodified mRNA can be used for CAR-T cell engineering without compromising function, eliminating the need for costly nucleoside modifications.

This study shows glycolytic flux supports human Th1 cell identity and effector function through STAT1 O-glycosylation, with inhibition of glycolysis or O-glycosylation reducing IFN-gamma production.

The paper identifies Clindamycin as a potential inhibitor of pyroptosis in tumor-associated macrophages by integrating network biology and pharmacophore modeling.

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.