A Low Containment CCHFV Entry Screening Platform Identifies Compounds with Antiviral Activity against Authentic CCHFV
Nallely Espinoza, Sophie N. Spector, Jessica R. Harmon, Payel Chatterjee, Markus H. Kainulainen, Mike Flint, Clarice Borges, Mahdis Manafi, Tsion Abay, Jessica R. Spengler, Éric Bergeron, Christina F. Spiropoulou, Lisa E. Hensley, Al Ozonoff, Touraj Aligholipour Farzani, Pardis Christine Sabeti
This study identifies eltrombopag olamine and quercetin as CCHFV entry inhibitors using a BSL-2 pseudotype screening platform validated against authentic CCHFV under BSL-4 conditions.
bioRxiv · Aug 30, 2026 · PreprintMicrobiology