De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
Huan Zhang, Naiara Santana-Codina, Qijia Yu, Clara L. Poupault, Claudia Campos, Xingping Qin, Nicole Sindoni, Marina Ciscar, Aparna Padhye, Miljan Kuljanin, Junning Wang, Matthew J. Dorman, Peter Bross, Andrew J. Aguirre, Stephanie K. Dougan, , Joseph Douglas Mancias
This study identifies that combining DHODH inhibition with BCL-XL targeting synergistically induces apoptosis in pancreatic cancer, offering a new combination therapy strategy.
Nature Communications · Jul 30, 2025Peer-reviewedCancer Biology