Author

Xingping Qin

Harvard UniversityORCID 0000-0003-3263-0843Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Kristopher A. SarosiekiD· 4 shared Bo R. RuedaiD· 2 shared Yusuke MatobaiD· 2 shared Abhishek A. ChakrabortyiD· 1 shared Adam G. PresseriD· 1 shared Ananthan SadagopaniD· 1 shared Andrew J. AguirreiD· 1 shared Aparna PadhyeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCancer Biology

Kristopher A. SarosiekORCID

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4 papers

Recent·Most cited

BCL-XL Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers

Tupa Basuroy, Treg M. Grubb, Ananthan Sadagopan, Xingping Qin, Kylee Madison, Autumn Hall, Belinda B. Willard, Sakari Vanharanta, Kristopher A. Sarosiek, Srinivas R. Viswanathan, Abhishek A. Chakraborty

The paper identifies BCL-XL dependence as a common vulnerability in various kidney cancer subtypes and develops a model to predict it using biomarkers like AMPK activation.

Cell Death and Disease · Sep 11, 2026Peer-reviewedCancer Biology

Extracellular vesicles facilitate the horizontal transfer of drug resistance and stem-like properties between ovarian tumor cells

Venkatesh Pooladanda, Rui Fang Xu, Dominique T. Zarrella, Yusuke Matoba, Chisa Shimada, Shaan Kumar, Eugene Kim, Paula J DiBenedetto, Xingping Qin, Kristopher A. Sarosiek, Madelyn Krueger, Narela Magrassi, Mansoor M. Amiji, Maryam Azimi Mohammadabadi, Ursula Winter, , Bo R. Rueda

This study shows that extracellular vesicles from ovarian cancer stem cells or drug-resistant cells transfer stem-like properties and drug resistance to sensitive cells via EZH2 signaling.

bioRxiv · Jan 23, 2026 · PreprintCancer Biology

De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

Huan Zhang, Naiara Santana-Codina, Qijia Yu, Clara L. Poupault, Claudia Campos, Xingping Qin, Nicole Sindoni, Marina Ciscar, Aparna Padhye, Miljan Kuljanin, Junning Wang, Matthew J. Dorman, Peter Bross, Andrew J. Aguirre, Stephanie K. Dougan, , Joseph Douglas Mancias

This study identifies that combining DHODH inhibition with BCL-XL targeting synergistically induces apoptosis in pancreatic cancer, offering a new combination therapy strategy.

Nature Communications · Jul 30, 2025Peer-reviewedCancer Biology

Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance

Xingping Qin, Adam G. Presser, Lissah Johnson, Yusuke Matoba, Brendan Shay, Weiyi Xu, Jonathan Choiniere, Cameron Fraser, Filip Garbicz, Johan K. E. Spetz, Stacey J. Yu, Mary H.C. Florido, Francesca Picucci, Yang Yang, Ronny Drapkin, , Kristopher A. Sarosiek

bioRxiv · Jun 24, 2025 · PreprintCancer Biology