Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.
Güleycan Lutfullahoğlu Bal, Kah Ying Ng, Eli Berzell, Anı Akpınar, Alex E. Ekvik, Lidiia Koludarova, Seyedehshima Naddafi, Clemens Raths, Tania Vane-Tempest, Jordyn J. VanPortfliet, Sarah M. O’Keefe, Arafath Kaja Najumudeen, Tuula A. Nyman, James Bruce Stewart, Andrew Phillip West, Brendan James Battersby
This study shows that errors in mitochondrial translation cause cellular stress and metabolic changes linked to disease and aging, independent of oxidative phosphorylation.
bioRxiv · Oct 13, 2025 · PreprintCell Biology