Alex E. Ekvik

The paper estimates ATP costs for mammalian cell growth and maintenance, showing that respiration alone cannot meet demands at fast growth rates, necessitating glycolytic ATP production.

This study shows that errors in mitochondrial translation cause cellular stress and metabolic changes linked to disease and aging, independent of oxidative phosphorylation.

The paper develops ATPGobble, a genetically encoded tool to manipulate ATP/ADP ratios in human cells, showing it increases energy demand and activates AMPK.

The paper develops a genetically encoded tool to manipulate mitochondrial membrane potential and shows it drives the integrated stress response from ATP synthase dysfunction.