Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration
Anna G. Flury, Leen Aljayousi, Hye-Jin Park, Mohammadparsa Khakpour, Jack Mechler, Siaresh Aziz, Jackson D. McGrath, Pragney Deme, Colby Sandberg, Fernando Gonzàlez Ibáñez, Olivia Braniff, Thi Ngo, Simira Smith, Matthew Velez, Denice Moran Ramirez, , Pinar Ayata
The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.
Neuron · Dec 24, 2024Peer-reviewedNeuroscience