Siaresh Aziz

Agomelatine drives sex-specific neuroprotection and reduced pathology in rat and human Alzheimer's models

This paper identifies agomelatine as a disease-modifying candidate for Alzheimer's disease, showing sex-specific neuroprotection and reduced pathology in both rat and human models.

Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

This study re-expresses embryonic motor neuron factors in mature neurons to reverse age-related degeneration and reduce ALS symptoms in a mouse model.

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

General and cell-type-specific aspects of the motor neuron maturation transcriptional program

The paper maps gene expression and chromatin accessibility changes in mouse spinal motor neurons during maturation, revealing dynamic regulatory elements and shared transcription factor motifs.

Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner

This study shows that altering song structure through unilateral vocal nerve resection affects neurogenesis in specific brain regions of songbirds, with no impact on HVC but reduced neurons in NCM and Area X.