Mohammadparsa Khakpour

A Novel Open-Source CellProfiler Pipeline for Automated, User-Friendly Hierarchical and K-Means Clustering of Microglial Morphology

The paper introduces a CellProfiler pipeline for automated clustering of microglial morphology using hierarchical and k-means methods, enabling user-friendly analysis of morphological subgroups.

The antipsychotic drug clozapine suppresses autoimmunity driving psychosis-like behavior in mice

This study shows clozapine reduces anti-NMDAR autoantibodies and psychosis-like behaviors in mice by suppressing autoimmunity.

Early micro and nanoscopic responses of microglia to blood-brain barrier modulation by transcranial-focused ultrasound

This study examines early microglial responses to FUS-induced BBB modulation, finding no significant density changes but increased cell elongation and altered synaptic interactions.

Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study

This study examines the effects of prenatal THC exposure on mouse brain development using MRI across the lifespan, finding sex-dependent neurodevelopmental impacts.

Transient, early, female-specific increase in cortical glial fibrillary acidic protein distribution in the Syrian hamster model of mild peripheral COVID-19

The paper quantifies astrogliosis in a Syrian hamster model of mild-moderate COVID-19, finding a transient, female-specific increase in GFAP signal density in the cortex at 3 days post-inoculation.

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.